
Tesamorelin 10mg
Tesamorelin – 10 mg | For Research Use Only – Not for Human Consumption
Tesamorelin is a synthetic peptidyl analog of growth hormone-releasing hormone (GHRH 1–44), engineered to resist degradation by dipeptidyl peptidase IV (DPP-IV) and extend its biological half-life. This stabilized GHRH analog selectively binds to GHRH receptors on pituitary somatotrophs, inducing endogenous pulsatile growth hormone (GH) secretion and subsequently elevating insulin-like growth factor-1 (IGF-1) levels.
Mechanistic Overview
Tesamorelin activates the hypothalamic-pituitary-somatotropic axis, enhancing GH release and downstream IGF-1 production, both of which regulate lipid metabolism, protein synthesis, and neuronal support functions. Its enhanced pharmacokinetics and receptor specificity make it a powerful tool for evaluating GH-mediated physiological and metabolic responses in research models.
Preclinical and experimental studies have shown Tesamorelin to:
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Stimulate lipolysis and reduce visceral adipose tissue accumulation
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Improve glucose and lipid metabolic parameters
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Enhance peripheral nerve integrity and myelin repair mechanisms
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Modulate neuronal plasticity and cognitive function through IGF-1–related pathways
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Exhibit neuroprotective effects in models of age-related cognitive decline
Research Applications
Tesamorelin is studied in in vitro and in vivo models for its potential in:
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GH deficiency and metabolic syndrome research
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Visceral adiposity and lipodystrophy models
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Peripheral neuropathy and neuroregeneration
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Cognitive aging and neurodegenerative disease pathways
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GH/IGF-1 axis modulation in systemic aging models
Its dual relevance in metabolic regulation and neuroendocrine health positions Tesamorelin as a valuable investigational compound in regenerative and therapeutic peptide research.
Product Specifications
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Peptide Content: 2 mg (lyophilized)
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Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
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Purity: >98% (validated by HPLC & MS)
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Storage: Store lyophilized at –20°C; reconstituted solution should be refrigerated at 2–8°C