TB-500 (Thymosin Beta-4) 10mg (43aa)

TB-500 (Thymosin Beta-4) – 10 mg | For Research Use Only – Not for Human Consumption

TB-500, a synthetic version of Thymosin Beta-4 (Tβ4), is a 43-amino acid peptide originally isolated from thymic tissue and highly conserved across vertebrate species. It is widely studied in preclinical models for its roles in tissue regeneration, cellular migration, and cytoskeletal remodeling. TB-500 serves as a critical modulator of actin dynamics and is actively investigated in models of injury repair and organ protection.

Mechanistic Overview

TB-500 exerts its biological activity by binding to G-actin monomers, thereby promoting actin polymerization and enabling cell migration, especially during the early phases of tissue repair. It is involved in numerous regulatory pathways associated with wound healing, angiogenesis, and inflammation.

Key investigational activities include:

• Promotion of angiogenesis through upregulation of VEGF (vascular endothelial growth factor)

• Anti-inflammatory signaling, reducing pro-inflammatory cytokine expression

• Oxidative stress mitigation, particularly in cardiac and neural tissues

• Support of extracellular matrix remodeling and tissue elasticity

• Enhancement of keratinocyte and fibroblast motility in dermal regeneration

Research Applications

TB-500 is studied in in vitro and in vivo models for its potential applications in:

• Muscle, tendon, and ligament healing

• Cardioprotection and myocardial repair following ischemic injury

• Central nervous system repair in models of neurodegeneration or trauma

• Ophthalmologic healing (e.g., corneal repair)

• Anti-aging research, focusing on cellular recovery and tissue resilience

Its broad tissue-distributive properties and wound-healing profile make TB-500 a key peptide for investigating regenerative and reparative pathways across multiple biological systems.

Product Specifications

• Peptide Content: 10 mg (lyophilized)

• Sequence: Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-His-Asp-Gly-Lys-Asn-Glu-Val-His-Ile-Gly-Glu-Glu-Ala-Glu-Asn-Gly-Asp

• Purity: >98% (confirmed via HPLC & MS)

• Storage: Store lyophilized at –20°C; reconstituted solution should be refrigerated at 2–8°C

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Bio Peptide Technologies is a chemical supplier. Bio Peptide Technologies is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Bio Peptide Technologies is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.

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2. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption