Cagril (10mg)

Cagril – 2 mg | For Research Use Only – Not for Human Consumption

Cagril is a long-acting, synthetic amylin analog designed to mimic the physiological actions of endogenous amylin, a peptide hormone co-secreted with insulin by pancreatic β-cells. Engineered with enhanced stability and an extended half-life, Cagril binds to the amylin receptor complex (calcitonin receptor + RAMPs), modulating central and peripheral pathways involved in satiety, glycemic control, and energy balance.

Mechanistic Overview

Cagril exerts its effects by replicating amylin’s regulatory functions, including:

• Delaying gastric emptying, reducing the rate of glucose absorption

• Enhancing satiety signaling via central appetite-regulating centers (e.g., area postrema and hypothalamus)

• Suppressing postprandial glucagon secretion to stabilize glycemic response

• Improving insulin sensitivity in adipose and hepatic tissues

In preclinical models, these actions contribute to:

• Reduced caloric intake and body weight

• Improved glucose homeostasis and insulin dynamics

• Preservation of pancreatic β-cell integrity under metabolic stress

• Potential cardiovascular modulation, including blood pressure and lipid profile improvements

Research Applications

Cagril is under investigation in in vivo and in vitro research models for its potential roles in:

• Obesity and weight management studies

• Appetite regulation and central metabolic signaling

• Postprandial glycemic control in type 2 diabetes models

• Adjunctive therapy with GLP-1 receptor agonists (e.g., Semaglutide)

• β-cell preservation and metabolic syndrome research

Its complementary action to incretin-based therapies makes it a valuable investigational agent in the development of multi-hormonal metabolic interventions.

Product Specifications

• Peptide Content: 2 mg (lyophilized)

• Type: Long-acting amylin receptor agonist

• Purity: >98% (verified by HPLC & MS)

• Storage: Store lyophilized at –20°C; reconstituted solution should be refrigerated at 2–8°C

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, or cosmetic.

Bio Peptide Technologies is a chemical supplier. Bio Peptide Technologies is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Bio Peptide Technologies is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.

All products are sold for research, laboratory, or analytical purposes only and are not for human consumption.

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1. Research Use Only: All products provided by Bio Peptide Technologies are intended solely for in-vitro laboratory research purposes. These materials are expressly forbidden for any form of human or animal use, ingestion, or administration.

The products offered on this platform are not formulated, designed, or intended to diagnose, cure, mitigate, treat, or prevent any diseases or medical conditions.

2. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption