KPV (10mg)

KPV (Lys–Pro–Val) 

CAS #: 86884-24-6
Molecular Formula: C₁₇H₃₁N₅O₄
Molecular Weight: 369.46 g/mol

Description

KPV (Lysine–Proline–Valine) is a naturally occurring tripeptide fragment derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), a peptide within the proopiomelanocortin (POMC) family. KPV retains α-MSH’s potent anti-inflammatory and immunomodulatory actions while being non-pigmentary and exhibiting exceptional biostability and tissue permeability.

KPV functions as a selective melanocortin-1 receptor (MC1R) agonist and an NF-κB pathway inhibitor, positioning it as a key modulator in the body’s innate anti-inflammatory and repair systems. It helps restore epithelial barrier function, downregulate pro-inflammatory cytokines, and support gut and skin homeostasis, making it an important peptide in protocols targeting autoimmunity, inflammatory bowel conditions, and post-injury recovery.

Mechanism of Action

🧩 1. MC1R Activation

KPV binds to the melanocortin-1 receptor (MC1R) on immune cells, epithelial cells, and keratinocytes. Activation of MC1R triggers intracellular cyclic AMP (cAMP) signaling, which in turn:

• Reduces transcription of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6).

• Increases production of anti-inflammatory mediators like IL-10.

• Modulates macrophage activity toward an M2 reparative phenotype, enhancing tissue regeneration.

This melanocortin-based mechanism provides a systemic and localized anti-inflammatory response without immunosuppression.

🧠 2. NF-κB Pathway Inhibition

NF-κB is a transcription factor central to inflammatory signaling. KPV directly suppresses NF-κB activation, preventing the expression of genes involved in chronic inflammation, oxidative stress, and immune dysregulation.
Through this pathway, KPV exerts:

• Reduced COX-2 and iNOS expression

• Decreased leukocyte migration

• Diminished cytokine and chemokine production

This makes KPV effective in mitigating chronic inflammatory responses associated with autoimmune and degenerative processes.

💊 3. Barrier Restoration and Epithelial Repair

KPV enhances tight junction protein expression (e.g., occludin, claudin, and ZO-1), supporting gut mucosal and dermal barrier integrity. This strengthens the epithelial defense against toxins, pathogens, and inflammatory mediators.
In intestinal models, KPV has demonstrated the ability to reverse colonic inflammation, reduce epithelial permeability, and normalize microbiota-immune interactions.

Clinical Potential & Research Applications

• Inflammatory Bowel Disease (IBD) and Leaky Gut: Improves mucosal healing and reduces intestinal permeability.

• Dermal Inflammation & Wound Healing: Enhances keratinocyte migration and angiogenesis, accelerating repair.

• Systemic Inflammation & Autoimmune Disorders: Downregulates pro-inflammatory cascades while preserving immune balance.

• Synergy in Regenerative Peptide Protocols: When combined with BPC-157 and TB-500, KPV enhances cellular recovery and reduces oxidative and inflammatory damage.

Key Benefits

• Potent anti-inflammatory and immune-regulating effects

• Supports epithelial and dermal regeneration

• Reduces oxidative stress and cytokine overload

• Restores barrier integrity in the gut and skin

• Complements BPC-157 and TB-500 for enhanced tissue repair

Storage & Handling

Store lyophilized KPV in a cool, dry environment protected from light. Once reconstituted with bacteriostatic water, refrigerate (2–8°C) and use within 20 days.

For Research Use Only. Not for human consumption.